Functional Network Mapping Reveals State-Dependent Response to IGF1 Treatment in Rett Syndrome
نویسندگان
چکیده
منابع مشابه
Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.
Rett Syndrome is a neurodevelopmental disorder that arises from mutations in the X-linked gene methyl-CpG binding protein 2 (MeCP2). MeCP2 has a large number of targets and a wide range of functions, suggesting the hypothesis that functional signaling mechanisms upstream of synaptic and circuit maturation may contribute to our understanding of the disorder and provide insight into potential tre...
متن کاملIGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients
Rett syndrome (RTT) is a devastating neurodevelopmental disorder that affects one in ten thousand girls and has no cure. The majority of RTT patients display mutations in the gene that codes for the methyl-CpG-binding protein 2 (MeCP2). Clinical observations and neurobiological analysis of mouse models suggest that defects in the expression of MeCP2 protein compromise the development of the cen...
متن کاملFunctional Annotation of Two Hypothetical Proteins Reveals Valuable Proteins Involved in Response to Salinity: An in silico Approach
Through the exponential development in the specification of sequences and structures of proteins by genome sequencing and structural genomics approaches, there is a growing demand for valid bioinformatics methods to define these proteins function. In this study, our objective is to identify the function of unknown proteins from UCB-1 pistachio rootstock and specify their class...
متن کاملKey Genes Involved in Wheat Response to Salinity Stress and Mapping their Gene Network
Extended Abstract Introduction and Objective: Considering the importance of salinity in wheat and the multigene nature of this trait, the present study was conducted to investigate the expression of key genes involved in the response of wheat to this stress and to create their network. Material and Methods: In this study, the expression of key genes (HKT, DREB, bZIP, NAC, and WARKY) involved...
متن کاملTreatment of epilepsy in Rett syndrome.
INTRODUCTION Epilepsy is very frequent in Rett syndrome (RTT) patients and often difficult to treat. Because most cases of RTT are caused by mutations in the MECP2 gene it is reasonable to assume that convulsions are based on common pathogenetic mechanisms and thus should have a similar response to antiepileptic drugs. PURPOSE To find the optimal treatment for epilepsy in RTT. METHODS We pe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain Sciences
سال: 2020
ISSN: 2076-3425
DOI: 10.3390/brainsci10080515